CC Cleaner lists this as an unwanted item

HKEY_CLASSES_ROOT\{80b8c23c-16e0-4cd8-bbc3-cecec9a78b79}

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Some believe this to be related to from the new Antivir 9, so did you install avira completely ?
If so try this - Avira AntiVir Uninstall Package & RegistryCleaner (choose appropriate version): http://www.avira.com/en/support/support_downloads.html.
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SYSPREP + Avira + HKEY_CLASSES_ROOT\{80b8c23c-16e0-4cd8-bbc3-cecec9a78b79}
1. Turn on 'Expert' mode in Avira configuration.
2. Navigate to General | Security, then uncheck "Protect files and registry..."
3. Add the following commands to the file %WINDIR%\Setup\Scripts\SetupComplete.cmd
REG ADD HKLM\System\CurrentControlSet\Services\avipbb /v InternalFlags /t REG_DWORD /d 0x0d1 /f
shutdown -t 300 -r -c "Machine must reboot to turn on Avira file and registry protection!"
4. Sysprep, image & deploy as normal.
As yet step 3 is untested, but you can manually turn on File and Reg protection on the target machine if you like - after the deployment is complete.
The real good news is that SYSPREP works with this protection disabled, and that bit is tested :p

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To get rid of it, first back up your registry. Then boot from a
standalone windows CD like "Bart PE" or "Ultimate Boot Disk for
Windows". Then launch Regedit from the CD, mount the windows
system registry from your hard drive as a hive, delete the key, unmount
the hive, then reboot.

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I downloaded the full install package for AV9 and also in one of your threads recently you had a tool to remove all the registry keys that I downloaded also. I uninstalled the app and ran the AntiVir cleaner for the registry after a reboot. Then used other reg cleaners like jv16 powertools and ccleaner and also searched all my profiles for folders left over ensuring it was off my system as best as possible. Note I did not verify the key was gone from the system at that time before reinstalling. I did reinstall the package and still had the same key show up as leading no-where. I read your post here an booted to safe mode under the main admin account and searched and found the key. I backed it up and then deleted it. Everything appears to be working fine here on my end. If I experience anything I will respond back here. Not sure why I could not delete the key if it was not leading anywhere in standard mode as my permissions showed I had control of it. I did not go into the config and uncheck protect files and registry entries from manipulation. Anyway it is gone and things seem fine.
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il est possible d'exclure l'analyse d'une clé de registre dans ccleaner ;) 
Avira AntiVir Personal - FREE Antivirus, Version 9 S'AUTO-PROTÈGE ;) 
Configurer AntiVir => Mode expert => Généralités => Sécurité => Case à cocher [X] "Protéger les fichiers et entrées d'inscription de toute manipulation" ;)DÉCOCHEZ LA CASE À VOS RISQUES ET PÉRILS ! Les autorisations sur la clé dans le registre peuvent être modifiées sans décocher la case. 
*** MODIFICATION : 
Contrôle total et propriétaire de la clé (et sous clés) = "Administrateurs" avec un "s" 
Contrôle total = l'utilisateur qui a installé l'antivirus avec pouvoir d'administrateur. 
Contrôle total = SYSTEM 
Le tout et suppression des autorisations venant des parents. 
*** MODIFICATION .