Do not use IExplorer version<7! Better: uninstall it completely!
Use Firefox, Flock or Opera instead (with webpage-threat advisors as belarcAdvisor, Sitehound, wot and McAfeeSiteAdvisor)
Don't forget NoScript! And hosts related software to protect zonemapping
Use Spybot Searcha&Destroy!
This piece of malware hijacks the IE start page and redirects to its own sites. This will then lead to a malicious web search page causing popup windows while using IE. The sites may also advertise trojans and/or install them directly without user consent.